Prophecy booster pack contains15 cards per pack. Distribution is 1 rare, 3 uncommons, and 11 commons. Released on June 5, 2000, Prophecy is the second set in the Masquerade block. Its expansion symbol are three crystals. The set contains 143 black-bordered cards (44 rare, 44 uncommon, and 55 commons).

Prophecy is set on the plane of Dominaria. Keld has declared war on Jamuraa in order to reclaim 'hero's blood', known also as tufa, which is a type of fossil fuel to run great machines. The city-states of Jamuraa form the Kipamu League and then repulse the invaders. The war bears a striking similarity to the Peloponnesian War between the Athenian Empire and the Peloponnesian League.

When released, was one of the least popular sets ever among tournament players. Though many casual players liked it because of the enormous Avatar and Winds cycle, both of which had a big effect at a big cost, it had relatively little impact on Standard tournaments. As of February 2012 only 21 cards from the Prophecy expansion have been reprinted.

The main theme and mechanic of the set was lands; specifically, whether lands were untapped or not. Similarly, the Rhystic cards gave the player an advantage if no other players paid a certain amount of mana. Prophecy introduced no keyword mechanics.